Drug Induced Qt Interval Prolongation
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Contents |
Etiology
-
- agents for ADHD
- amphetamine/ dextroamphetamine (Adderall, dexadrine)
- lisdexamfetamine ( Vyvanse)
- atomoxetine ( Strattera)
- methylphenidate ( Ritalin, Concerta) & dexmethylphenidate
-
- class 1B
- class 1C
- sotalol*
- ibutilide
- amiodarone#
- dronedarone ( Multaq)
-
- sertraline
- fluoxetine
- paroxetine
- sibutramine ( Meridia)
- citalopram ( Celexa) & escitalopram ( Lexapro)
- dolasetron
- droperidol
- ondansetron
- domperidone
- granisetron
- palonosetron [8]
- promazine
- astemizole
- terfenadine
- diphenydramine
- hydroxyzine
- arsenic trioxide
- tamoxifen
- lapatinib ( Tykerb)
- sunitinib ( Sutent)
- toremifene ( Fareston)
- dasatinib ( Sprycel)
- nilotinib ( Tasigna)
- vandetanib ( Caprelsa)
-
- erythromycin
- clarithromycin
- troleandromycin (TAO)
- azithromycin
- albuterol, levalbuterol
- isoproterenol
- metaproterenol
- epinephrine
- terbutaline
- salmeterol ( Serevent)
- salbutamol ( Ventolin)
- cardiac agents
- bepridil ( Vascor)
- dopamine
- moexipril/ HCTZ (Uniretic)
- norepinephrine
- epinephrine
- dobutamine
- isradipine ( Dynacirc)
- nicardipine ( Cardene)
- ranolazine ( Ranexa)
- ephedrine
- isoproterenol
-
- thioridazine ( Mellaril)
- chlorpromazine
- mesoridazine ( Serentil)
- fluphenazine [8]
- perphenazine [5]
- haloperidol
- sertindole
- risperidone ( Risperdal) [3]
- ziprasidone ( Geodon)
- pimozide ( Orap)
- clozapine ( Clozaril)
- quetiapine ( Seroquel)
- aripiprazole ( Abilify)
- paliperidone ( Invega)
- asenapine ( Saphris)
- iloperidone ( Fanapt)
- loxapine
- molindone
- olanzapine [8]
- sumitriptan [8]
- zolmitriptan [8]
- urogenital agents
- other
- amantadine
- apomorphine ( Apokyn)
- arsenic
- chloral hydrate
- chloroquine
- cisapride
- cocaine
- domperidone
- encainide
- felbamate
- FK506
- foscarnet
- fosphenytoin
- galantamine
- halofantrine ( Halfan)
- indapamide ( Lozol)
- ketanserin
- levomethadyl ( Orlaam) - off market
- lithium carbonate
- Metoclopramide ( Reglan)
- methadone
- midodrine
- nefazodone
- octreotide ( Sandostatin)
- orphenadrine ( Norflex)
- oxytocin (Pitocin)
- pentamidine
- probucol (off US market)
- quinine
- ritodrine
- salmeterol ( Serevent)
- tacrolimus
- terodiline
- tizanidine ( Zanaflex)
- * most common agents implicated in torsades de pointes
- # amiodarone is rarely associated with torsades de pointes
More General Terms
Additional Terms
References
- Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 151
- Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
- Prescriber's Letter 8(4):19 2001
- Prescriber's Letter 11(11): 2004 Drugs That Prolong the QT Interval and/or Induce Torsades de Pointes Detail-Document#: [1] Detail-Document#: [2] (subscription needed) [3]
- Prescriber's Letter 17(4): 2010 Drug-induced Long QT Interval CHART: Drug-induced Long QT Interval COMMENTARY: QT Prolongation, Torsades de Pointes, & Medication Safety Detail-Document#: [4] (subscription needed) [5]
- Prescriber's Letter 18(9): 2011 CHART: Drug-induced Long QT Interval COMMENTARY: QT Prolongation, Torsades de Pointes, & Medication Safety Detail-Document#: [6] (subscription needed) [7]
- Prescriber's Letter 19(1): 2012 Drug-Induced Long QT Interval Detail-Document#: [8] (subscription needed) [9]
- Geriatrics at your Fingertips, 13th edition, 2011 Reuben DB et al (eds) American Geriatric Society
