Drug Adverse Effects Angiotensin Ii Receptor Antagonist

Adverse-effects

well tolerated
similar to placebo
reduced incidence of cough relative to ACE inhibitors
urticaria & angioedema (rare)
no increased risk of cancer; refs [2] report RR = 1.1-1.2; but FDA concludes no excess risk of cancer with ARBs [4]
no increased cardiovascular risk [3]

Kaiser Permanente Northern California Regional Drug Formulary, Update 9/99
Sipahi I et al Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials The Lancet Oncology, Early Online Publication, 14 June 2010 Not ye indexed in PubMed doi:10.1016/S1470-2045(10)70106-6 [1]
Bangalore S et al. Angiotensin receptor blockers and risk of myocardial infarction: Meta-analyses and trial sequential analyses of 147 020 patients from randomised trials. BMJ 2011 Apr 26; 342:d2234 PMID: [2]
- Julius S et al. Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: The VALUE randomised trial. Lancet 2004 Jun 19; 363:2022-31. PMID: [3]
FDA Drug Safety Communication: 06/02/2011 No increase in risk of cancer with certain blood pressure drugs- Angiotensin Receptor Blockers (ARBs) [4]
- Bhaskaran K et al. Angiotensin receptor blockers and risk of cancer: Cohort study among people receiving antihypertensive drugs in UK General Practice Research Database. BMJ 2012 Apr 24; 344:e2697 PMID: [5]