Drug Adverse Effects Angiotensin Converting Enzyme Inhibitor

From Anvita Health Wiki

Adverse-effects

• cough

• may occur after several weeks to 1 year
• dose reduction may alleviate cough
• switching ACE inhibitor is generally of little benefit

• hyperkalemia & hyponatremia via inhibition of aldosterone secretion*
• hypotension & renal insufficiency with reduced preload
• acute renal insufficiency may develop in patients with bilateral renal artery stenosis*
• rash
• angioedema (1%) [6]

• generally occurs within 1st week
• may occur years later
• more common in blacks than whites

• dysgeusia
• increased serum creatinine

• 15-20% initial increase is acceptable [4]
• decline in creatinine within 1 month, otherwise discontinue

• proteinuria may or may not [2] be present
• leukopenia
• vasomotor rhinitis
• may exacerbate psoriasis [4]

• * Serum creatinine & K+ should be checked within 1 week of starting an ACE inhibitor.

More General Terms

• drug adverse effect(s)

References

1. Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 117
2. contribution from Peter Baylor, M.D. VAMC, UCSF Fresno
3. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
4. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
5. Prescriber's Letter 9(4):19 2002
6. Prescriber's Letter 9(11):62 2002

drug adverse effects of ACE inhibitors