Dopamine Transporter

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Pathology 5 Pharmacology 6 More General Terms 7 Additional Terms 8 Internet Database 9 References

Function

• amine transporter
• terminates the action of dopamine by its high affinity Na+-dependent reuptake into presynaptic terminals
• interacts with PRKCABP & TGFB1I1

Structure

• homooligomer; disulfide-linked
• belongs to the Na+:neurotransmitter symporter (SNF) family

Compartment

• membrane

Pathology

• down-regulation of dopamine transporters in part compensates for loss of dopaminergic terminals
• down-regulation is mitigated by exogenous dopamine (from levodopa, Sinemet) shorteing duration of levodopa action

Pharmacology

• SLC6A3 is the target of psychomotor stimulants such as amphetamines or cocaine

More General Terms

• solute carrier family 6
• adenosine triphosphatase (ATPase)
• plasma membrane protein
• glycoprotein

Additional Terms

• dopamine (Inotropin, Dopastat)

Internet Database

Kegg: [1]
OMIM: 126455
Prosite: [2]
Prosite: [3]
Prosite: [4]
UniProt: [5]
Entrez gene: 6531

References

1. UniProt [6]
2. NIEHS-SNPs [7]
3. Wikipedia; Note: dopamine transporter entry [8]
4. Niznik HB et al The dopamine transporter is absent in parkinsonian putamen and reduced in the caudate nucleus. J Neurochem 56:192 1991 PMID: [9]
5. Giros B, Caron MG. Molecular characterization of the dopamine transporter. Trends Pharmacol Sci. 1993 Feb;14(2):43-9. Review. PMID: [10]
6. Troiano AR et al. PET demonstrates reduced dopamine transporter expression in PD with dyskinesias. Neurology 2009 Apr 7; 72:1211. PMID: [11]
   - Vingerhoets FJG. Dyskinesia in Parkinson disease: Back for the future? Neurology 2009 Apr 7; 72:1202. PMID: [12]

dopamine transporter (solute carrier family 6 member 3, DA transporter, DAT, DAT1, SLC6A3)