Dna Damage

From Anvita Health Wiki

Contents 1 More Specific Terms 2 Introduction 3 More General Terms 4 Additional Terms 5 References

More Specific Terms

• apurinic/apyrimidinic (AP) site
• Comet assay (comet tail moment)
• DNA base lesion

Introduction

• Damage to DNA in the form of DNA base lesions or apurinic/ apyrimidinic (AP)-sites. These may be repaired by DNA repair mechanisms, or if extensive, the cell may signal the need for apoptosis.

• DNA damage may induce activity of sodium-hydrogen exchanger ( NHE-1), which leads to a rise in intracellular pH
• deamidation of antiapoptic proteins, including bcl-xL may facilitate apoptosis
• Assays for different types of DNA damage vary in utility

• comet assay
• unscheduled DNA synthesis

• Tandemly repeated BRCT domains are characteristic of proteins involved in DNA damage signaling.

• MDC1

More General Terms

• biochemistry

Additional Terms

• DNA repair

References

1. UniProt [1]
2. Zhao R et al. Inhibition of the Bcl-xL deamidation pathway in myeloproliferative disorders. N Engl J Med 2008 Dec 25; 359:2778. PMID: [2]

DNA damage