Diphtheria&tetanus Toxoid&pertussis&hemophilus B Vaccine

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Contents 1 Indications 2 Contraindications 3 Dosage 4 Pharmacokinetics 5 Notes 6 More General Terms 7 Additional Terms 8 References

Indications

• active immunization of infants & children 2 months-5 years against diphtheria, tetanus, pertussis & hemophilus b when indications for DPT & HIB coincide

Contraindications

• patients > 7 years of age
• patients with cancer
• immunodeficiency
• children with a history of neurologic disorders
• history of serious adverse reactions to pertussis vaccine
• do not use for treatment of diphtheria, tetanus or pertussis infection
• hypersensitivity to hemophilus b polysaccharide vaccine ( thimerosal)

• pregnancy-category -
• safety in lactation -

Dosage

• Children 2 months-6 years (2-3 months recommended)

• 0.5 mL IM on 3 occasions at 4-8 week intervals
• reinforcing dose 1 year after 3rd injection

• Injection: 5 mL vials

Pharmacokinetics

• elimination: liver Adverse reactions:
• convulsions, screaming episodes, malaise, sleepiness, focal neurologic signs, shock, collapse, chills, erythema, induration, rash, urticaria, local tenderness, arthralgias, fever, swelling, warmth, increased risk of hemophilus b infections in the week following vaccination, allergic or anaphylactic reactions (rare)
• all serious adverse reactions must be reported to the FDA

Notes

• If adverse reaction occurs, immunization should be completed with diphtheria & tetanus toxoid (dT, Td).
• A nodule may be present at the site of injection for a few weeks.

More General Terms

• toxoid
• vaccine

Additional Terms

• Bordetella pertussis
• diphtheria
• Haemophilus influenzae
• tetanus

References

Kaiser Permanente Northern California Regional Drug  Formulary, 1998

diphtheria, tetanus toxoid, pertussis & hemophilus b vaccine (Tetramune, DTP-Hib)