Diflunisal

From Anvita Health Wiki

Contents 1 Introduction 2 Dosage 3 Pharmacokinetics 4 Adverse-effects 5 Drug-interactions 6 Laboratory 7 More General Terms 8 Internet Database 9 References

Introduction

• Tradename Dolobid.

Dosage

• 100 mg loading dose, then 500 mg PO every 12 hours.

• Tabs: 250, 500 mg.

Pharmacokinetics

• food deceases the rate, but not extent of diflusinal absorption
• diflusinal elimination is dose-dependent
  

• elimination via liver
• 1/2life = 8-12 hours
• 1/2life = 5-20 hours
• protein binding = >99 %
• elimination by hemodialysis = -
• elimination by peritoneal dialysis = -

Adverse-effects

• nausea/vomiting
• peptic ulceration
• gastrointestinal bleeding
• dizziness
• drowsiness
• edema
  
• drug adverse effects of NSAIDs

Drug-interactions

• aluminum & magnesium hydroxide may decrease diflunisal absorption
• diflunisal may decrease renal elimination of:

• Li+
• digoxin
• methotrexate

• diflunisal may decrease steady state warfarin concentrations but does not appear to affect anticoagulant response
• bioavailablity of diflunisal is decreased by coadminstration of aspirin
  
• drug interaction(s) of lithium carbonate with NSAIDs
• drug interaction(s) of NSAIDs with SSRIs
• drug interaction(s) of aspirin with NSAIDs
• drug interaction(s) of NSAIDs with beta blockers
• drug interaction(s) of NSAIDs with ARBs
• drug interaction(s) of NSAIDs with ACE inhibitors
• drug interaction(s) of NSAIDs, diuretics & angiotensin II receptor antagonists
• drug interaction(s) of NSAIDs, diuretics & ACE inhibitors
• drug interaction(s) of NSAIDs & loop diuretics
• drug interaction(s) of NSAIDs & aspirin

Laboratory

• specimen:

• serum, plasma ( EDTA), urine
• stable for at least 14 days at -20 degrees C

• methods:

• serum/ plasma: HPLC, GC, fluorometry
• urine: GC, HPLC

• interferences:

• diflunisal interferes with FPIA for salicylate

More General Terms

• non-steroidal anti-inflammatory agent (NSAID)

Internet Database

PubChem: 3059

References

1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
2. Clinical Guide to Laboratory Tests, NW Tietz (ed) 3rd ed, WB Saunders, Philadelpha 1995

diflunisal (Dolobid)