Defender Against Cell Death 1

From Anvita Health Wiki

Contents 1 Introduction 2 Function 3 Structure 4 Compartment 5 More General Terms 6 Internet Database 7 References

Introduction

• Subunit of oligosaccharyltransferase complex that inititates N-glycosylation. Also plays anti- apoptotic role during development. Homozygous mutants die in utero.

Function

• subunit of oligosaccharyltransferase complex that inititates N-glycosylation
• plays anti- apoptotic role during development; loss of the DAD1 protein triggers apoptosis ( putative)

Structure

• belongs to the DAD/OST2 family

Compartment

• membrane ( putative)

More General Terms

• membrane protein
• protein subunit

Internet Database

UniProt: [1]
Entrez gene: 1603
Kegg: [2]
OMIM: 600243

References

1. UniProt [3]
2. Rampon C, Jiang CH, Dong H, Tang YP, Lockhart DJ, Schultz PG, Tsien JZ, Hu Y. Effects of environmental enrichment on gene expression in the brain. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12880-4. PMID: [4]
3. NIEHS-SNPs [5]

dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; oligosaccharyl transferase subunit DAD1; defender against cell death 1; DAD-1 (DAD1)