Decitabine

From Anvita Health Wiki

Contents 1 Monitor 2 Mechanism-of-action 3 Notes 4 More General Terms 5 Internet Database 6 References

Monitor

• liver function tests at baseline [2]

Mechanism-of-action

• pyrimidine analog incorporated into DNA, traps DNA methyltransferases, inhibitor of DNA hypermethylation in cancer

Notes

• in clinical trials for

• myelodysplastic syndrome
• CML
• acute myeloid leukemia
• other solid tumors (lung, ovary, prostate)

More General Terms

• antimetabolite
• antineoplastic agent (chemotherapeutic agent)

Internet Database

PubChem: 16886
PubChem: 451668
PubChem: 465300

References

1. Lyons et al. Curr Opin Investig Drugs 4:1442-50, 2003 PMID: [1]
2. Prescriber's Letter 17(7): 2010 Recommended Lab Monitoring for Common Medications Liver Function Test Scheduling Detail-Document#: [2] (subscription needed) [3]

decitabine or 5-aza-2'-deoxycytidine