Dcc Interacting Protein 13 Alpha
From Anvita Health Wiki
Contents |
Function
- regulation of cell proliferation
- response to extracellular signals
- mediated by an early endosomal compartment
- links Rab5 to nuclear signal transduction
- binds RAB5A leading to recruitment to endosomal membranes & role in cell proliferation
- binds DCC
- binds catalytic domain of the inactive form of AKT2 through PID domain
- binds PIK3CA
- binds subunits of the NuRD/ MeCP1 complex
- overexpression has proapoptotic effect
Compartment
- early endosomal membrane, peripheral membrane, nucleus
- translocation into the nucleus upon release from endosomal membranes following internalization of EGF
Expression
- expressed in heart, ovary, pancreas, skeletal muscle
More General Terms
Internet Database
OMIM: 604299
Prosite: [1]
Prosite: [2]
UniProt: [3]
References
UniProt [4]
