Cytochrome P450 2d6 Genotyping

From Anvita Health Wiki

Contents 1 Indications 2 Clinical-significance 3 More General Terms 4 Additional Terms 5 References

Indications

• assessment of tamoxifen metabolism

Clinical-significance

• cytochrome P450 2D6 activates tamoxifen to 4- hydroxy-N-desmethyl- tamoxifen ( endoxifen) the most active metabolite of tamoxifen (in terms of estrogen binding
• individuals with homozygous mutations may be poor metabolizers of tamoxifen; thus poor activators of tamoxifen & poor responders to therapy
• apparently the may be ultra-rapid metabolizer forms as well [2]

More General Terms

• molecular diagnostic test

Additional Terms

• cytochrome P450 2D6 (cytochrome P450 2D, cytochrome P450 DB1, debrisoquine-4-hydroxylase, CYP2D6)

References

1. Cytochrome P450 2D6 Genotype for Tamoxifen Hormonal Therapy Mayo Clinic [1]
2. DxID

cytochrome P450 2D6 genotyping