Cytochrome C Oxidase Subunit 1
From Anvita Health Wiki
Contents |
Function
- subunit of cytochrome c oxidase, the component of the respiratory chain that catalyzes the reduction of oxygen to water
- subunits 1-3 form the functional core of the enzyme complex.
- MT-CO1 is the catalytic subunit of the enzyme
- electrons originating in cytochrome c are transferred via the copper A center of subunit 2 & heme A of subunit 1 to the bimetallic center formed by heme A3 & copper B
- energy metabolism; oxidative phosphorylation
Structure
- belongs to the heme- copper respiratory oxidase family
Compartment
- mitochondrial inner membrane; multi-pass membrane protein
Pathology
- defects in MT-CO1 are a cause of
More General Terms
- transmembrane 12 protein
- enzyme catalytic subunit
- cytochrome c oxidase subunit
- mitochondrial membrane protein
Internet Database
Entrez gene: 4512
Kegg: [1]
OMIM: 114500
OMIM: 220110
OMIM: 500008
OMIM: 516030
OMIM: 535000
OMIM: 550500
Prosite: [2]
Prosite: [3]
UniProt: [4]
References
