Cytochrome B Reductase 1
From Anvita Health Wiki
Contents |
Function
- ferric- chelate reductase that reduces Fe+3 to Fe+2
- present at the brush border of duodenal enterocytes where it probably reduces dietary Fe+3 thereby facilitating its transport into the mucosal cells
- uses ascorbate as electron donor
- may be involved in extracellular ascorbate recycling in erythrocyte membranes
- may also act as a ferrireductase in airway epithelial cells
- Cofactor: binds 2 heme groups non- covalently ( putative)
Structure
- contains 1 cytochrome b561 domain
Compartment
- membrane
Expression
- present in erythrocyte membranes (at protein level)
- also expressed in respiratory epithelium
- induced by iron deficiency (at protein level)
Pathology
- defects in CYBRD1 may be a cause of primary hereditary hemochromatosis
More General Terms
Internet Database
References
UniProt [2]
