Cysteine Rich Pak1 Inhibitor

From Anvita Health Wiki

Contents 1 Function 2 Compartment 3 Expression 4 Pathology 5 More General Terms 6 Internet Database 7 References

Function

• negative regulator of PAK1
• interacts with PAK1

Compartment

• cytoplasm, membrane, nucleus
• translocated to the nuclear compartment upon hormonal treatment by estrogen

Expression

• widely expressed
• highest espression observed in trachea, prostate & adrenal glands
• up-regulated by estrogen

Pathology

• expressed in many cancer cell lines including breast cancer cells
• loss of CRIPAK in breast tumors might contribute to hormonal independence

More General Terms

• uncharacterized protein

Internet Database

Kegg: [1]
UniProt: [2]

References

UniProt [3]

cysteine-rich PAK1 inhibitor (CRIPak, CRIPAK)