Cysteine Rich Motor Neuron 1 Protein

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 More General Terms 6 Internet Database 7 References

Function

• role in CNS development by interacting with growth factors implicated in motor neuron differentiation & survival ( putative)
• role in capillary formation & maintenance during angiogenesis ( putative)
• modulates BMP activity by affecting its processing & delivery to the cell surface
• interacts with BMP4 & BMP7

Structure

• N-glycosylated
• contains 4 antistasin-like domains
• contains 1 IGFBP domain
• contains 6 VWFC domains

Compartment

• cell membrane, secreted

Expression

• expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver & small intestine
• expressed in blood vessels (at protein level)

More General Terms

• glycoprotein
• membrane protein

Internet Database

OMIM: 606189
Prosite: [1]
Prosite: [2]
UniProt: [3]

References

UniProt [4]

cysteine-rich motor neuron 1 protein (CRIM-1, cysteine-rich repeat-containing protein S52, CRIM1)