Cyclic Amp Dependent Transcription Factor Atf 6 Beta

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Expression 6 More General Terms 7 Internet Database 8 References

Function

• transcription factor
• role in unfolded protein response pathway ( UPR)
• activates UPR target genes induced during ER stress
• binds DNA on the 5'-CCAC[GA]- 3' half of the ER stress response element (ERSE) ( 5'-CCAATN(9)CCAC[GA]- 3') when NF-Y is bound to ERSE
• homodimer & heterodimer with ATF6-alpha
• dimer interacts with the nuclear transcription factor Y ( NF-Y) trimer via direct binding to NF-Y subunit C (NF-YC)
• during unfolded protein response an approximative 60 kD fragment containing the cytoplasmic transcription factor domain is released by proteolysis - cleavage is probably performed sequentially by site-1 & site-2 proteases

Structure

• belongs to the bZIP family, ATF subfamily
• contains 1 bZIP domain
• basic domain functions as a nuclear localization signal
• basic leucine-zipper domain is sufficient for association with NF-Y trimer & binding to ERSE
• N-glycosylated

Compartment

• endoplasmic reticulum membrane
• processed form: nucleus
• under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus

Alternative-splicing

• named isoforms=2

Expression

• ubiquitous

More General Terms

• transcription factor (TF)
• glycoprotein
• DNA-binding protein
• membrane protein

Internet Database

OMIM: 600984
Prosite: [1]
UniProt: [2]

References

UniProt [3]

cyclic AMP-dependent transcription factor ATF-6 beta (activating transcription factor 6 beta, ATF6-beta, cAMP-responsive element-binding protein-like 1, cAMP response element-binding protein-related protein, Creb-rp, protein G13, CREBL1, G13)