Cub Domain Containing Protein 1

From Anvita Health Wiki

Contents 1 Function 2 Compartment 3 Alternative-splicing 4 Expression 5 More General Terms 6 Internet Database 7 References

Function

• cell adhesion
• cell matrix association
• tumor progression & metastasis
• interacts with N-cadherin, P-cadherin, syndecan-1, syndecan-4, serine protease ST14, SRC, protein kinase C gamma
• phosphorylated on Tyr by SRC, YES, protein kinase C gamma, suramin; phosphorylated in response to dissociation of integrin alpha-6, beta-4 from laminin-5

Compartment

• cell membrane
• shedding may lead to a soluble peptide

Alternative-splicing

• named isoforms=3

Expression

• highly expressed in mitotic cells
• low expression during interphase
• expressed in skeletal muscle, colon > kidney, small intestine, placenta, lung
• expressed in human tumor cell lines, colorectal cancer, breast carcinoma, lung cancer

More General Terms

• membrane protein
• glycoprotein
• phosphoprotein

Internet Database

Prosite: [1]
UniProt: [2]

References

UniProt [3]

CUB domain-containing protein 1 (transmembrane & associated with src kinases, membrane glycoprotein gp140, subtractive immunization M plus HEp3 associated 135 kDa protein, SIMA135, CD318 antigen, CDCP1, TRASK, UNQ2486/PRO5773)