Crumbs Protein Homolog 3

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Expression 6 More General Terms 7 Internet Database 8 References

Function

• role in the establishment of cell polarity in mammalian epithelial cells
• regulates the morphogenesis of tight junctions
• interacts with MPP5, PARD6A & INADL

Structure

• PDZ-binding motif is involved in the interactions with PARD6A & MPP5

Compartment

• apical cell membrane, cell junction, tight junction
• localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells

Alternative-splicing

• named isoforms=2

Expression

• preferentially expressed in epithelial tissues
• expressed at high levels in lung, kidney, retina, colon & mammary glands
• expressed at moderate levels in liver, spleen, pancreas, placenta & prostate

More General Terms

• glycoprotein
• membrane protein

Internet Database

UniProt: [1]

References

UniProt [2]

Crumbs protein homolog 3 (CRB3)