Crumbs Homolog 2

From Anvita Health Wiki

Contents 1 Function 2 Compartment 3 Alternative-splicing 4 Expression 5 Pathology 6 More General Terms 7 Additional Terms 8 Internet Database 9 References

Function

• polarized cells morphogenesis

Compartment

• isoform 1: cell membrane
• isoform 2: secreted

Alternative-splicing

• named isoforms=3

Expression

• expressed in retina, fetal eye, brain, kidney, choroid cell lines > lung, placenta, heart

Pathology

• defects in CRB2 may be a cause of retinitis pigmentosa
• defects in CRB2 may be a cause of Leber congenital amaurosis

More General Terms

• membrane protein
• secreted protein
• glycoprotein

Additional Terms

• Leber congenital amaurosis
• retinitis pigmentosa (RP)

Internet Database

OMIM: 204000
OMIM: 268000
Prosite: [1]
Prosite: [2]
Prosite: [3]
Prosite: [4]
Prosite: [5]
UniProt: [6]

References

UniProt [7]

crumbs homolog 2 (CRB2)