Convection Enhanced Delivery

From Anvita Health Wiki

Contents 1 Introduction 2 Procedure 3 More General Terms 4 Additional Terms 5 References

Introduction

• Investigational procedure for targeted delivery in gene therapy.

Procedure

• adenovirus vectors bearing either therapeutic or marker genes can be injected into specific cells of the thalamus
• specific axonal connections from neurons in the thalamus to neurons in the cortex enable spread of the adenovirus vector with its gene cargo to cortical regions, where the therapeutic or marker gene-encoded proteins are expressed

More General Terms

• clinical procedure

Additional Terms

• gene therapy

References

1. Kells AP et al Efficient gene therapy-based method for the delivery of therapeutics to primate cortex. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2407-11. Epub 2009 Feb 4. PMID: [1]
   - UCSF Medical Center News, April 14, 2009 Researchers Develop New Gene Therapy Technique for Brain Disorders [2]

convection-enhanced delivery