Contact System

From Anvita Health Wiki

Introduction

• The contact system is a biochemical process that triggers local activation of several proteolytic systems. It plays a role in initiation & amplification of surface-mediated inflammatory processes via:
• activation of:

• complement C1
• coagulation factor XI (intrinsic pathway of coagulation)
• coagulation factor XII (intrinsic pathway of coagulation)
• prorenin
• plasminogen
• prekallikrein

• cleavage of HMW kininogen

• release of bradykinin

More General Terms

• biochemistry

References

- Bergamaschini L, Donarini C, Gobbo G, Parnetti L, Gallai V. Activation of complement and contact system in Alzheimer's disease. Mech Ageing Dev. 2001 Nov;122(16):1971-83. PMID: [1] contact system