Constipation
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Contents |
More Specific Terms
Introduction
Etiology
- health habits
- low fiber intake
- inactivity
-
- barium sulfate
- ferrous sulfate
- lithium carbonate [12]
- bismuth
- ion exchange ( bile) resins ( cholestyramine)
- sympathomimetics
- opiates
- anticholinergic agents
- antipsychotics [12]
- chronic stimulant laxative use
- irritable bowel syndrome
- structural lesions
- depression
- endocrine & metabolic causes
Epidemiology
- the most common digestive complaint in the USA
- affects over 2% of the population
- 2-3 times more common in women than men
- marked increase after age 65
- comorbidity
- environmental influences
- over- reporting
Laboratory
- serum chemistries
Diagnostic-procedures
Radiology
- plain abdominal films generally not useful
- barium enema (after relief of obstruction)
- colonic transit studies using radiographic markers
Complications
- hemorrhoids
- anal fissure
- rectal prolapse
- stercoral ulcer
- melanosis coli
- cathartic colon
- fecal impactation
- ischemic colitis
- colonic volvulus
- colonic perforation
- fecal incontinence
- urinary incontinence
- cardiovascular disorders
- arrhythmias
- syncope
- angina [4]
- Alarm features
- rectal bleeding, positive fecal occult blood
- family history
- anemia
- acute onset in an elderly person
- disease interaction(s) of constipation with urinary incontinence
Differential-diagnosis
Management
- general considerations
- disimpactation if indicated
- adequate fluid intake
- adequate dietary fiber
- adequate physical activity
- stepwise management of chronic constipation [11]
- stop all medications that may contipate, if possible
- increase dietary fiber intake to 6-25 grams/day; increase fluid intake to >= 1.5 L/day; increase physical activity; bulk laxitive may be used provides fluid intake is >= 1.5 L/day
- if step 2 fails, add sorbitol 70% 15-30 mL every 12-24 hours; max 150 mL/day
- add stimulant laxative ( senna or bisocodyl) 2-3 times per week
- use tap water enema or saline enema twice a week
- oil retention enema for refractory constipation
- comment: recommend step 4 prior to step 3
- pharmaceutical agnets
- bulk-forming laxatives
- osmotic agents
- lactulose
- sorbitol (70%)
- glycerin
- polyethylene glycol ( Miralax)
- stool softeners (not usually recommended [3])
- stimulants probably don't perpetuate altered colonic motility [5]
- enemas
- bowel retraining, biofeedback
- probiotics may be of benefit for infants [8]
More General Terms
Additional Terms
- diagnostic criteria for constipation
- feces (stool)
- ileus
- intestinal pseudo-obstruction
- medical conditions associated with constipation
- pharmaceutical agents associated with constipation
References
- Harrison's Principles of Internal Medicine, 13th ed. Companion Handbook, Isselbacher et al (eds), McGraw-Hill Inc. NY, 1995, pg 829-39
- Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 297-300
- Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
- Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 242-43
- Prescriber's Letter 12(3): 2005 Constipation Myths Detail-Document#: [1] (subscription needed) [2]
- Journal Watch 25(10):82, 2005 Borowitz SM, Cox DJ, Kovatchev B, Ritterband LM, Sheen J, Sutphen J. Treatment of childhood constipation by primary care physicians: efficacy and predictors of outcome. Pediatrics. 2005 Apr;115(4):873-7. PMID: [3]
- Prescriber's Letter 14(5): 2007 Medications for constipation Detail-Document#: [4] (subscription needed) [5]
- Coccorullo P et al. Lactobacillus reuteri (DSM 17938) in infants with functional chronic constipation: A double-blind, randomized, placebo- controlled study. J Pediatr 2010 Oct; 157:598. PMID: [6]
- Kamm MA et al. Oral bisacodyl is effective and well-tolerated in patients with chronic constipation. Clin Gastroenterol Hepatol 2011 Jul; 9:577. PMID: [7]
- Prescriber's Letter 19(2): 2012 CHART: Treatment of Constipation in Children GUIDELINES: Managing functional constipation in children (2011) GUIDELINES: Evaluation and Treatment of Constipation in Infants and Children: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (2006) Detail-Document#: [8] (subscription needed) [9]
- Geriatric Review Syllabus, 7th edition Parada JT et al (eds) American Geriatrics Society, 2010
- Geriatrics at your Fingertips, 13th edition, 2011 Reuben DB et al (eds) American Geriatric Society
- NIH Institute and Center Resources [10]
- National Guideline Clearinghouse
- Prevention of constipation in the older adult population. (Registered Nurses Association of Ontario) ngc-guideline: [11]
- Functional constipation and soiling in children University of Michigan Health System ngc-guideline: [12]
- Evaluation and treatment of constipation in infants and children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. ngc-guideline: [13]
- Constipation in children and young people. Diagnosis and management of idiopathic childhood constipation in primary and secondary care. National Collaborating Centre for Women's and Children's Health. ngc-guideline: [14]
