Complement Factor H

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Expression 4 Polymorphism 5 More General Terms 6 Additional Terms 7 Internet Database 8 References

Function

• binds to C3b enhancing conversion of C3b to iC3b (inactive form) by Factor I
• also increases the rate of dissociation of the C3bBb complex ( C3 convertase) & the (C3b)NBB complex ( C5 convertase) in the alternative complement pathway
• binds to heparin & C-reactive protein [4]

Structure

• each Sushi domain binds C1 esterase inhibitor

Expression

• expressed by the liver & secreted into plasma

Polymorphism

• polymorphism associated with macular degeneration

More General Terms

• complement

Additional Terms

• complement cascade
• complement factor H like protein DDESK59
• complement factor H like protein Down16
• complement factor H like protein-1 (H36)

Internet Database

UniProt: [1]
OMIM: 134370

References

1. Baron M, Norman DG, Campbell ID. Protein modules. Trends Biochem Sci. 1991 Jan;16(1):13-7. Review. PMID: [2]
2. Clinical Diagnosis and Management by Laboratory Methods, 18th ed, J.B. Henry (ed), W.B. Saunders, Philadelphia, PA, 1991 pg 835
3. OMIM [3]
4. Klein RJ, Zeiss C, Chew EY, Tsai JY, Sackler RS, Haynes C, Henning AK, Sangiovanni JP, Mane SM, Mayne ST, Bracken MB, Ferris FL, Ott J, Barnstable C, Hoh J. Complement factor H polymorphism in age-related macular degeneration. Science. 2005 Apr 15;308(5720):385-9. Epub 2005 Mar 10. PMID: [4]

complement factor H