Collagen 25 Alpha 1

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Expression 6 Pathology 7 More General Terms 8 Additional Terms 9 Internet Database 10 References

Function

• inhibits fibrillization of beta amyloid peptide during elongation
• assembly of amyloid fibrils into protease-resistant aggregates
• binds heparin
• binds to fibrillized forms of beta amyloid peptide 40 & more frequently with beta amyloid peptide 42
• glycosylated

Structure

• forms homodimers & homotrimers
• hydroxylated on 11% of PRO & 49% of LYS
• contains 7 collagen-like domains

Compartment

• membrane
• after proteolytic cleavage, CLAC is secreted

Alternative-splicing

• named isoforms=3

Expression

• expressed predominantly in brain

Pathology

• deposited in primitive or neuritic amyloid plaques
• proteolytic cleavage by furin protease to yield soluble collagen-like Alzheimer amyloid plaque component

More General Terms

• collagen subunit
• glycoprotein
• membrane protein

Additional Terms

• A4 amyloid peptide; beta-peptide
• amyloid precursor protein; A4/beta amyloid precursor protein (APP)

Internet Database

UniProt: [1]

References

UniProt [2]

collagen 25 alpha-1 (CLAC-P, Alzheimer disease amyloid-associated protein, AMY, [Contains: Collagen-like Alzheimer amyloid plaque component (CLAC)], COL25A1)