Coatomer

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 More General Terms 5 References

Function

• one of 2 components ( ARF & coatomer) necessary for assembly & budding of vesicles mediating biosynthetic transport across GOLGI stack
• binds to dilysine motifs
• reversibly associates with Golgi non- clathrin-coated vesicles
• mediates biosynthetic protein transport from endoplasmic reticulum ( ER) via the Golgi to trans Golgi network
• budding from Golgi membranes
• retrograde Golgi-to- ER transport of dilysine-tagged proteins
• recruited by membranes associated with ADP-ribosylation factors
• Golgi structural integrity
• processing, activity, & endocytic recycling of LDL receptors

Structure

• protein complex of 7 distinct subunits ( COPs) alpha-COP, beta-COP, beta'-COP, gamma-COP, delta-COP, epsilon-COP, zeta-COP

Compartment

• cytoplasm, Golgi
• coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it

More General Terms

• membrane protein
• molecular complex

References

- Orcl L, Palmer DJ, Amherdt M, Rothman JE. Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol. Nature. 1993 Aug 19;364(6439):732-4. PMID: [1] coatomer