Coagulation Factor Viii Autoantibody

From Anvita Health Wiki

Contents 1 Etiology 2 Epidemiology 3 Clinical-manifestations 4 Laboratory 5 Management 6 More General Terms 7 Additional Terms 8 References

Etiology

• autoimmune diseases
• postpartum state
• hypersensitivity reactions to drugs
• low-grade lymphocytic malignancy

• low-grade non-Hodgkin's lymphoma
• chronic lymphocytic leukemia

• occur in older patients without known underlying disorder

Epidemiology

• postpartum: occurs most often after birth of 1st child

Clinical-manifestations

• massive subcutaneous or intramuscular bleeding
• postpartum

• commonly 1-3 month delay prior to onset of symptoms
• bleeding tendency
• variable course

Laboratory

• prolonged aPTT, NOT corrected with addition of normal plasma

Management

• immunosuppressive therapy
• acute bleeding

• porcine factor VIII (generally less reactive with anti- human factor VIII)
• prothrombin complex concentrate
• recombinant factor VIIa concentrate
• plasmapheresis

• immunosuppressive therapy

• high-dose oral corticosteroids with cyclophosphamide 2 mg/kg/day

• postpartum

• spontaneous resolution in most patients with 12-18 months of delivery
• course shortened by immunosuppressive agents but not by corticosteroids alone

More General Terms

• autoantibody
• anticoagulant

Additional Terms

• coagulation factor VIII alloantibody
• coagulation factor VIII inhibitor in plasma
• coagulation factor VIII; antihemophilic factor; AHF; procoagulant component; contains: factor VIIIa heavy chain, 200 kD & 92 isoforms; factor VIII B chain; factor VIIIa light chain (F8, F8C)
• hemophilia A; factor VIII deficiency

References

1. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
2. Schiller G, in: UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001

coagulation factor VIII autoantibody