Coagulation Factor V Autoantibody

From Anvita Health Wiki

Contents 1 Etiology 2 Epidemiology 3 Pathology 4 Laboratory 5 More General Terms 6 Additional Terms 7 References

Etiology

• spontaneous (20%)
• exposure to bovine factor V present in topical thrombin or 'surgical glue' used in surgical procedures (80%)

Epidemiology

• uncommon

Pathology

• heterologous antibodies to bovine factor V cross-react with human factor V
• serious, even fatal bleeding may occur

Laboratory

• prolongation of PT & aPTT; neither corrects with addition of normal plasma

More General Terms

• autoantibody
• anticoagulant

Additional Terms

• coagulation factor V inhibitor in plasma
• coagulation factor V; activated protein C cofactor; proaccelerin, labile factor; contains: coagulation factor V heavy chain; coagulation factor V light chain (F5)

References

Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998

coagulation factor V autoantibody