Coagulation Disorder

From Anvita Health Wiki

Contents 1 More Specific Terms 2 Etiology 3 Clinical-manifestations 4 Management 5 More General Terms 6 Additional Terms 7 References

More Specific Terms

• coagulation factor deficiency
• disseminated intravascular coagulation (DIC)
• hypercoagulability
• localized intravascular coagulation

Etiology

• hemophilia
• vitamin K deficiency
• coagulation factor inhibitor - mimics hemophilia
• disseminated intravascular coagulation
• localized intravascular coagulation
• liver dysfunction

• associated with pathologic thrombosis, fibrinolysis or both
• prolongs PT, then aPTT
• eventually dysfibrinogenemia occurs

Clinical-manifestations

• ( coagulation defect)
• delayed bleeding after trauma
• bleeding into deep joints, muscle, retroperitoneum
• hematomas & hemarthrosis

Management

• use fresh frozen plasma to replace coagulation factors
• use cyroprecipitate* as an adjunct to fresh frozen plasma
  

• * cyroprecipitate contains factor VIII, vWF, fibrinogen

More General Terms

• hematologic disease (blood disorder, blood dyscrasia)

Additional Terms

• bleeding disorder/diathesis
• coagulation
• platelet disorder

References

1. Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 321
2. Medical Knowledge Self Assessment Program (MKSAP) 14, American College of Physicians, Philadelphia 2006

coagulation disorder