Cnga2/cnga4/cngb1b Complex

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 More General Terms 4 References

Function

• forms the cyclic nucleotide-gated cation channel of olfactory sensory neurons
• Ca+2- calmodulin exerts its inhibitory effect in cAMP sensitivity by binding to IQ-like motif of CNGA4 & preferably binds to the channel in the closed state
• inhibition by PIP3 of the CNG channel probably occurs via CGNA2 binding

Structure

• subunits: CNGA2, CNGA4, CNGB1b

More General Terms

• molecular complex
• cyclic nucleotide-gated cation channel

References

UniProt [1]

CNGA2/CNGA4/CNGB1b complex