Chloride Channel Protein Clc Kb

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 Pathology 6 Notes 7 More General Terms 8 Internet Database 9 References

Function

• voltage-gated chloride channel
• chloride channels have several functions including

• regulation of cell volume
• membrane potential stabilization
• signal transduction
• transepithelial transport

• may be important in urinary concentrating mechanisms
• interacts with barttin ( BSND)
• forms heteromers with BSND in the thick ascending limb of Henle & more distal segments

Structure

• belongs to the chloride channel (TC 2.A.49) family
• contains 2 CBS domains

Compartment

• membrane

Expression

• expressed predominantly in the kidney

Pathology

• defects in CLCNKB are the cause of Bartter syndrome type 3

Notes

• compared with CLCNKA/ BSND, CLCNKB/ BSND is more sensitive to pH & less responsive to Ca+2

More General Terms

• Cl- channel
• glycoprotein
• transmembrane 12 protein

Internet Database

UniProt: [1]
Entrez gene: 1188
Kegg: [2]
OMIM: 602023
OMIM: 607364
Prosite: [3]

References

UniProt [4]

chloride channel protein ClC-Kb; chloride channel Kb; ClC-K2 (CLCNKB)