Chitobiosyldiphosphodolichol Beta Mannosyltransferase

From Anvita Health Wiki

Contents 1 Function 2 Compartment 3 Pathology 4 More General Terms 5 Internet Database 6 References

Function

• participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation
• assembly of dolichol-pyrophosphate-GlcNAc(2)-Man(5) on the cytoplasmic surface of the ER
• glycosylation

Compartment

• endoplasmic reticulum

Pathology

• defects in ALG1 are the cause of congenital disorder of glycosylation type 1K ( CDG-1k)

More General Terms

• glycosyltransferase
• membrane protein

Internet Database

OMIM: 605907
OMIM: 608540
UniProt: [1]

References

UniProt [2]

chitobiosyldiphosphodolichol beta-mannosyltransferase (GDP-mannose-dolichol diphosphochitobiose mannosyltransferase, GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase, beta-1,4-mannosyltransferase, mannosyltransferase-1, MT-1, asparagine-linked glycosylation protein 1 homolog, Hmat-1, ALG1, HMAT1, HMT1, PSEC0061 UNQ861/PRO1870)