Cerebrospinal Fluid

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Contents 1 Introduction 2 More General Terms 3 Additional Terms 4 References

Introduction

• 70% secreted by choroid plexus, 30% from brain parenchyma. It is absorbed into the systemic circulation through the arachnoid villa. >80% of the protein in CSF originates from plasma, the remainder from intrathecal synthesis.

• CSF protein electrophoresis (after concentration)

• ultrafiltrate of plasma
• all proteins visible on electrophoresis are <150 kD
• prominent prealbumin band
• 2 transferrin bands

• beta-1 transferrin
• beta-2 transferrin

• used largely to detect intrathecal production of IgG

• IgG/ albumin ratio < 0.27 considered normal

• Total volume (adult): 150 mL (100-160 mL [3])
• CSF: production: 0.35 mL/min, 500 mL/day
• Also see CSF analysis

More General Terms

• extracellular compartment (extracellular space)
• body fluid

Additional Terms

• cerebrospinal fluid (CSF) protein electrophoresis
• cerebrospinal fluid analysis
• intracranial pressure (ICP)
• lumbar spinal puncture (LP, Quincke puncture, spinal tap, rachicentesis, rachiocentesis)
• reference values for CSF constituents

References

1. Fundamentals of Clinical Chemistry 3rd ed., N.W. Teitz ed., W.B. Saunders, 1988, pg 339
2. Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 1065-67
3. Tietz Textbook of Clinical Chemistry, 2nd ed. Burtis CA & Ashwood ER (eds), WB Saunders Co, Philadelphia PA, 1993
4. Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996

cerebrospinal fluid