Cenp E

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 More General Terms 6 Internet Database 7 References

Function

• minus-end directed microtubule motor
• probable kinetochore motor
• accumulates just before mitosis at the G2 phase of the cell cycle
• probably important for chromosome movement &/or spindle elongation
• interacts with CENP-F, BUBR1 kinase & PRC1

Structure

• belongs to the kinesin-like protein family
• contains 1 kinesin-motor domain

Compartment

• kinetochore, spindle, centromere
• associates with kinetochores during congression
• relocates to the spindle midzone at anaphase
• quantitatively discarded at the end of cell division

Alternative-splicing

• named isoforms=3

More General Terms

• adenosine triphosphatase (ATPase)
• guanosine triphosphatase (GTPase)
• prenyl protein

Internet Database

UniProt: [1]
Kegg: [2]
OMIM: 117143
Prosite: [3]
Prosite: [4]

References

UniProt [5]

centromere protein-E (CENP-E, CENPE)