Cellular Senescence

From Anvita Health Wiki

Contents 1 Introduction 2 Notes 3 More General Terms 4 Internet Database 5 References

Introduction

• In vitro:

• cessation of proliferation by multiple subcultures of cultured cells

• In vivo:

• presumptive process constrained by structural properties of organs & tissues & paracrine & endocrine influence of other constituents of the organism
  

• Characterized by:

• cessation of mitosis
• telomere shortening
• tumor promoter-like activity

• enhancement of neoplastic transformation of proneoplastic cells in vivo

• expression of biomarkers for cellular senescence

• p16ink4a [2]

• resistance to apoptosis

Notes

• accumulation of p16ink4a in senescent cells may disrupt tissue structure & function & contribute to age-related pathology [2]; clearance of p16ink4a-containing cells may prevent &/or attenuate age-related degenerative pathology [2]

More General Terms

• senescence

Internet Database

OMIM: 116960

References

1. Eugenia Wang, University of Louisville, in: Microarray Technology and Aging Workshop, March 14, 2003
2. Baker DJ et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 2011 Nov 10; 479:232 PMID: [1]
   - Peeper DS. Old cells under attack. Nature 2011 Nov 10; 479:186 PMID: [2]

cellular (relicative) senescence