Cd163
From Anvita Health Wiki
Contents |
Function
- acute phase-regulated receptor
- clearance & endocytosis of hemoglobin/ haptoglobin complexes by macrophages
- uptake & recycling of iron
- induces a cascade of intracellular signals that involves tyrosine kinase-dependent Ca+2 mobilization, IP3 production & secretion of IL6 & CSF1
Compartment
- membrane
- soluble form (sCD163) is produced by proteolytic shedding
Expression
- induced by anti-inflammatory mediators
- suppressed by proinflammatory
- lipopolysaccharide, IGN-gamma, TNF-alpha
Pathology
- sCD163 is a disease marker of inflammatory conditions
More General Terms
Internet Database
OMIM: 605545
Entrez gene: 9332
Prosite: [1]
Prosite: [2]
UniProt: [3]
References
