Cathepsin D

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Pathology 5 Polymorphism 6 More General Terms 7 Internet Database 8 References

Function

• acid protease active in intracellular protein breakdown
• specificity similar to, but narrower than, that of pepsin A
• does not cleave the 4- Gln-|- His-5 bond in B chain of insulin

Structure

• consists of a light chain & a heavy chain
• belongs to the peptidase A1 family

Compartment

• lysosome, melanosome

Pathology

• defects in CTSD are the cause of neuronal ceroid lipofuscinosis 10
• potential role in pathogenesis of

• breast cancer
• Alzheimer disease

Polymorphism

• Val-58 allele is significantly overrepresented in demented patients (11.8%) compared with non- demented controls (4.9%
• carriers of the Val-58 allele have a 3.1-fold increased risk for developing AD than non- carriers

More General Terms

• cathepsin
• aspartic proteinase; carboxyl acid protease

Internet Database

UniProt: [1]
Kegg: [2]
OMIM: 116840
Prosite: [3]
Entrez gene: 1509

References

UniProt [4]

cathepsin-D (CTSD, CPSD)