Carboxyhemoglobin In Blood

From Anvita Health Wiki

Contents 1 Reference-interval 2 Clinical-significance 3 Increases 4 Methods 5 Specimen 6 More General Terms 7 Additional Terms 8 References

Reference-interval

• non- smokers: 0.5-1.5% of hemoglobin
• smokers (1-2 packs/day): 4-5% of hemoglobin
• heavy smokers (> 2 packs/day): 8-9% of hemoglobin
• toxic: > 20% of hemoglobin
• lethal: > 50% of hemoglobin

Clinical-significance

• levels of carbon monoxide of < 10% may increase disturbances of cognitive function or aggravate pre-existing heart disease
• levels of 15-25% may cause dizziness & nausea
• 1/2 life is reduced from 5 hours to 80 minutes with oxygen administration & to 24 minutes with hyperbaric O2 (3 atmospheres)

Increases

• smoking
• exposure to gases:

• defective furnaces
• automobile exhaust
• coal gas
• most combustibles
• methylene chloride

• hemolytic disease
• blood in intestine

Methods

• colorimetric
• GLC

Specimen

• whole blood ( heparin)
• stable for > 4 months in filled, well-capped tube
• do NOT use oxalate
• collect specimen BEFORE treatment with oxygen

More General Terms

• clinical hematology test

Additional Terms

• carboxyhemoglobin

References

Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,  W.B. Saunders, 1995

carboxyhemoglobin in blood