Carbonic Anhydrase 2

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 Pathology 6 More General Terms 7 Internet Database 8 References

Function

• reversible hydration of carbon dioxide interacts with SLC4A4
• interaction with SLC4A7 regulates SLC4A7 transporter activity
• role in osteoclast function & bone resorption
  

• H3CO3 <--> CO2 + H2O
  
• Cofactor: Zn+2

Structure

• belongs to the alpha- carbonic anhydrase family

Compartment

• cytoplasm

Expression

• only carbonic anhydrase isozyme expressed in kidney
• also expressed in brain & erythrocytes

Pathology

• defects in CA2 are the cause of carbonic anhydrase 2 deficiency

More General Terms

• carbonic anhydrase (dehydratase)
• membrane protein

Internet Database

UniProt: [1]
Kegg: [2]
OMIM: 259730
Prosite: [3]
Entrez gene: 760

References

1. OMIM [4]
2. UniProt [5]
3. GeneReviews [6]

carbonic anhydrase-2 (carbonic anhydrase-B, CA2)