Carbachol
From Anvita Health Wiki
Contents |
Introduction
- Tradenames: Isopto Carbachol, Miostat.
Indications
Contraindications
- acute iritis
- inflammation of the anterior chamber
Dosage
- ophthalmic: 1-2 drops QID PRN
- intraocular: 0.5 mL instilled into anterior chamber before or after securing sutures
- Intraocular (Miostat) 0.01% (1.5 mL)
- Ophthalmic (Isopto Carbachol) 0.75%, 1.5%, 2.25%, 3% (15 mL)
Pharmacokinetics
- miosis occurs in 10-20 minutes
- duration of action 4-8 hours
- maximal reduction of intraocular pressure within 4 hours
Adverse-effects
- not common (1-10%)
- uncommon (< 1%)
- headache, ciliary spasm with temporary loss of visual acuity, corneal clouding, persistent bullous keratopathy, postoperative keratitis, retinal detachment, transient ciliary & conjunctival injection, transient hypotension, asthma, increased peristalsis, stomach cramps, diarrhea
Mechanism-of-action
- acetylcholine analog with relatively more nicotinic receptor agonist activity & less muscarinic receptor agonist activity than acetylcholine [3]
- direct-acting cholinergic agent that causes miosis
- reduction of intraocular pressure
More General Terms
Additional Terms
Internet Database
PubChem: 5831
PubChem: 2551
PubChem: 521353
References
- Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
- Kaiser Permanente Northern California Regional Drug Formulary, 1998
- The Pharmacological Basis of Therapeutics, 8th ed. Gilman et al, eds. Permagon Press/McGraw Hill pg 143
