Capsaicin

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Dosage 4 Adverse-effects 5 Mechanism-of-action 6 Notes 7 More General Terms 8 Internet Database 9 References

Introduction

• Tradename: Zostrix, Qutenza.

Indications

• temporary relief of pain due to:

• rheumatoid arthritis
• osteoarthritis
• neuralgia ( diabetic, shingles, post Herpetic neuralgia)
• musculoskeletal pain [4]

Dosage

• apply up to QID
• Qutenza must be applied to the skin by a healthcare professional
• it can be used for 60 minutes, once every 3 months [5]

• Cream: 0.025%, 0.075%. 45 g
• Transdermal patch Qutenza: 8%

Adverse-effects

• burning of skin & mucous membranes
• stinging
• erythema

Mechanism-of-action

• depletion of substance P

Notes

• Qutenza cost: $700/treatment (2010)

More General Terms

• dermatologic agent

Internet Database

PubChem: 2548
PubChem: 1548943

References

1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
3. Geriatrics Review Syllabus, American Geriatrics Society, 5th edition, 2002-2004
4. Journal Watch 24(11):91, 2004 Mason L, Moore RA, Derry S, Edwards JE, McQuay HJ. Systematic review of topical capsaicin for the treatment of chronic pain. BMJ. 2004 Apr 24;328(7446):991. Epub 2004 Mar 19. Review. <PubMed> PMID: [1] <Internet> [2]
5. FDA NEWS RELEASE, Nov. 17, 2009 FDA Approves New Drug Treatment for Long-Term Pain Relief after Shingles Attacks [3]
   - Qutenza prescribing information [4]
6. Prescriber's Letter 17(5): 2010 COMMENTARY: Qutenza: A High Dose Capsaicin Patch GUIDELINES: Treatment of Postherpetic Neuralgia (QSS-ANN, 2004) GUIDELINES: Prevention of Herpes Zoster (ACIP, 2008) Detail-Document#: [5] (subscription needed) [6]

capsaicin (Zostrix, Qutenza)