Capecitabine

From Anvita Health Wiki

Contents 1 Indications 2 Dosage 3 Adverse-effects 4 Mechanism-of-action 5 More General Terms 6 Additional Terms 7 Internet Database 8 References

Indications

• metastatic colon carcinoma ( FDA approved)
• stage IV breast cancer (2nd-4th line agent) [2]
• inoperable advanced gastric cancer - in combination with a platinum-based regimen

Dosage

• Oral agent

Adverse-effects

• causes less diarrhea, nausea & mouth ulcers than 5-FU
• more likely than 5-FU to cause pain & swelling of the hands & feet

Mechanism-of-action

• metabolized to 5-fluorouracil ( 5-FU)
• similar therapeutic effect as 5-FU

More General Terms

• antineoplastic agent (chemotherapeutic agent)

Additional Terms

• 5-fluorouracil [5-FU] (Fluoroplex, Efudex, Adrucel)

Internet Database

PubChem: 60953
PubChem: 400633

References

1. Prescriber's Letter 8(7):40 2001
2. National Guideline Clearinghouse
   - Guidance on the use of capecitabine for the treatment of locally advanced or metastatic breast cancer National Institute for Clinical Excellence (NICE) ngc-guideline: [1]
   - Capecitabine for the treatment of advanced gastric cancer. National Institute for Health and Clinical Excellence (NICE) ngc-guideline: [2]

capecitabine (Xeloda)