Camp Responsive Element Binding Protein 3 Like Protein 4

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 Pathology 6 More General Terms 7 Internet Database 8 References

Function

• transcriptional activator
• may play a role in the unfolded protein response
• binds to the UPR element (UPRE) but not to CRE element
• preferentially binds to DNA consensus sequence 5'-T[GT]ACGT[GA][GT]- 3'
• has transcriptional activation activity from UPRE
• binds to NF-kappa-B site & has transcriptional activation activity from NF-kappa-B-containing regulatory elements
• binds DNA as a dimer
• controlled by regulated intramembrane proteolysis
• following ER stress, a fragment containing the cytoplasmic transcription factor domain is released by proteolysis

Structure

• N-glycosylated in the C-terminal region
• belongs to the bZIP family. ATF subfamily.
• contains 1 bZIP domain

Compartment

• endoplasmic reticulum membrane
• processed form: nucleus
• under ER stress, cleaved N-terminal cytoplasmic domain translocates into nucleus
• may also be located in Golgi apparatus

Expression

• expressed in prostate
• expressed in prostatic luminal epithelial cells
• also expressed in brain, pancreas, skeletal muscle > small intestine, testis, leukocyte & thymus
• induced by androgens

Pathology

• expressed in breast & prostate cancer cell lines

• expression is significantly more abundant in prostate cancer than in benign prostatic hyperplasia

More General Terms

• basic leucine zipper (bZIP) family protein
• DNA-binding protein
• transcription factor (TF)
• glycoprotein
• membrane protein

Internet Database

OMIM: 607138
OMIM: 607495
UniProt: [1]

References

UniProt [2]

cAMP responsive element-binding protein 3-like protein 4 (androgen-induced basic leucine zipper protein, AIbZIP, cyclic AMP-responsive element-binding protein 4, attaching to CRE-like 1, ATCE1, transcript induced in spermiogenesis protein 40, Tisp40, hJAL, CREB3L4, AIBZIP, CREB4, JAL)