Ca+2 Binding Mitochondrial Carrier Protein Scamc 3

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Expression 6 More General Terms 7 Internet Database 8 References

Function

• Ca+2-dependent mitochondrial solute carrier
• mitochondrial solute carriers shuttle metabolites, nucleotides, & cofactors through the mitochondrial inner membrane
• may act as ATP-Mg/Pi exchanger that mediates the transport of Mg- ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria
• may interact with hepatitis B virus ( HBV) protein S
  

• Kinetic parameters:

• KM=1.3 mM for AMP
• KM=0.54 mM for ADP
• KM=0.31 mM for ATP
• KM=0.22 mM for ATP-Mg
• KM=1.4 mM for Pi
• Vmax=68 umol/min/g enzyme with AMP as substrate
• Vmax=73 umol/min/g enzyme with ADP as substrate
• Vmax=65 umol/min/g enzyme with ATP as substrate
• Vmax=79 umol/min/g enzyme with ATP-Mg as substrate
• Vmax=70 umol/min/g enzyme with Pi as substrate

Structure

• belongs to the mitochondrial carrier family
• contains 3 EF-hand domains
• contains 3 solcar repeats

Compartment

• mitochondrial inner membrane

Alternative-splicing

• named isoforms=4

Expression

• present in various cell lines (at protein level)
• expressed at low levels in most tissues examined
• highest expression in brain, skeletal muscle & pancreas

More General Terms

• membrane protein
• Ca+2 binding protein
• mitochondrial protein
• solute carrier family 25 (SLC25, SLC25A)

Internet Database

OMIM: 608746
Prosite: [1]
UniProt: [2]

References

UniProt [3]

Ca+2-binding mitochondrial carrier protein SCaMC-3 (small Ca+2-binding mitochondrial carrier protein 3, mitochondrial ATP-Mg/Pi carrier protein 2, mitochondrial Ca+2-dependent solute carrier protein 2, solute carrier family 25 member 23, SLC25A23, APC2, MCSC2, SCAMC3)