Ca+2 Binding Atopy Related Autoantigen 1

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Expression 6 Pathology 7 More General Terms 8 Internet Database 9 References

Function

• induces T helper 1-mediated autoreactivity, which is accompanied by the release of IFNG

Structure

• contains 2 EF-hand domains

Compartment

• membrane ( putative)

Alternative-splicing

• named isoforms=3

Expression

• expressed in epithelial cell line
• strongly expressed in epidermal keratinocytes & dermal endothelial cells

Pathology

• causes an allergic reaction in human
• binds to IgE from atopic dermatitis patients
• identified as an IgE autoantigen in atopic dermatitis patients with severe skin manifestations

More General Terms

• Ca+2 binding protein
• membrane protein

Internet Database

Kegg: [1]
OMIM: 605084
Prosite: [2]
UniProt: [3]

References

UniProt [4]

Ca+2-binding atopy-related autoantigen 1 (Atopy-related autoantigen CALC, ara CALC, allergen hom s 4, CBARA1, CALC)