Ca+2 Activated Chloride Channel Regulator 4

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 Pathology 6 More General Terms 7 Internet Database 8 References

Function

• may be involved in mediating Ca+2-activated chloride conductance
• processed at a monobasic residue to yield a larger N-terminal & a smaller C-terminal cleavage products of 90 to 110 & 30 to 35 kD, respectively ( putative)

Structure

• N-glycosylated ( putative)
• belongs to the CLCR family
• contains 1 VWFA domain

Compartment

• cell membrane
• apical cell membrane
• secreted ( putative)
• the C-terminus 30 kD form is anchored to the membrane ( putative)
• the N-terminus 110 kD form is released from the membrane triggered by an unknown stimulus

Expression

• primarily expressed in the digestive tract, mainly in colon
• detected in smaller amounts in brain, urogenital organs, testis, & salivary & mammary glands
• highly expressed in the epithelial layer & submucosal gland of the inferior turbinate mucosa
• lower levels in the epithelial layer of nasal polyp

Pathology

• down-regulated in oral tongue squamous cell carcinomas

More General Terms

• glycoprotein
• membrane protein

Internet Database

Kegg: [1]
UniProt: [2]

References

UniProt [3]

Ca+2-activated chloride channel regulator 4; Ca+2-activated chloride channel family member 4; hCLCA4; Ca+2-activated chloride channel protein 2; CaCC-2; hCaCC-2; contains: Ca+2-activated chloride channel regulator 4, 110 kD form, Ca+2-activated chloride channel regulator 4, 30 kD form (CLCA4, CaCC2, UNQ562/PRO1124)