C Type Lectin Domain Family 12 Member B

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Expression 6 More General Terms 7 Internet Database 8 References

Function

• cell surface receptor
• protects target cells against NK cell-mediated lysis
• modulates signaling cascades
• mediates tyrosine phosphorylation of target MAP kinases
• interacts with PTPN6 & PTPN11

Structure

• homodimer
• contains 1 ITIM motif
• the phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases
• contains 1 C-type lectin domain

Compartment

• cell membrane

Alternative-splicing

• named isoforms=2

Expression

• detected in colon, heart, kidney, liver, lung, mammary gland, ovary, spleen & testis

More General Terms

• phosphoprotein
• glycoprotein
• membrane protein
• C-type lectin superfamily

Internet Database

Prosite: [1]
Prosite: [2]
UniProt: [3]

References

UniProt [4]

C-type lectin domain family 12 member B (macrophage antigen H, CLEC12B)