Braf V600e Mutation

From Anvita Health Wiki

Contents 1 Indications 2 Clinical-significance 3 Procedure 4 More General Terms 5 Additional Terms 6 References

Indications

• elibigiblity for treatment of metastatic melanoma with vemurafenib ( Zelboraf)

Clinical-significance

• mutation present in about 1/2 of late-stage melanomas

Procedure

• polymerase chain reaction to identify point mutation Val-600 to Glu-600 in the BRAF gene

More General Terms

• molecular diagnostic test

Additional Terms

• cutaneous melanoma

References

1. FDA NEWS RELEASE: Aug. 17, 2011 FDA approves Zelboraf and companion diagnostic test for late-stage skin cancer

BRAF V600E mutation