Bexarotene

From Anvita Health Wiki

Contents 1 Indications 2 Dosage 3 Mechanism-of-action 4 Notes 5 More General Terms 6 References

Indications

• treatment of cutaneous T cell lymphoma.
• used off-label for lung cancer, breast cancer, & Kaposi's sarcoma

Dosage

• oral agent

• Capsules: 75 mg

Mechanism-of-action

• binds retinoid X receptors
• stimulates production of apoE

Notes

• in transgenic mice overexpressing beta-amyloid, bexarotene

• increases expression of apoE in the brain
• reductes beta-amyloid (both soluble & in plaques)
• reverses cognitive impairment & loss of behavioral skills

More General Terms

• antineoplastic agent (chemotherapeutic agent)
• dermatologic agent

References

1. PubMed Health: Bexarotene [1]
2. National Cancer Institute: Bexarotene [2]
3. Wikipedia: Bexarotene [3]
4. Cramer PE et al. ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models. Science 2012 Mar 23; 335:1503 PMID: [4]
   - Strittmatter WJ. Old drug, new hope for Alzheimer's disease. Science 2012 Mar 23; 335:1447. PMID: [5]

bexarotene (Targretin)