Betamethasone

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Contraindications 4 Dosage 5 Adverse-effects 6 Drug-interactions 7 More General Terms 8 Internet Database 9 References

Introduction

• Systemic agent: Tradename Celestone.

Indications

• seborrheic dermatitis, atopic dermatitis
• neurodermatitis
• anogenital pruritis
• psoriasis
• inflammatory phase of xerosis
• late phase of allergic dermatitis or irritant dermatitis
• fetal lung maturation

Contraindications

• Caution: Halogenated hydrocarbons should not be used on face

• rebound worsening
• steroid-induced rosacea or atrophy
  

• pregnancy category = c
• safety in lactation = -
• safety in lactation = ?

Dosage

• 0.5-9.0 mg IM/ PO QD
• 12 mg IM QD x 2 doses ( fetal lung maturation) Tabs: 0.6 mg Liquid: 0.6 mg/5 mL. Injection: 6 mg/mL, 5 mL vials.
  

• Topical agent: Tradenames: Diprosone, Valisone.

• 0.05 or 0.1% cream/ointment/lotion BID/ TID
  

• Augmented betamethasone: Tradename: Diprolene. Very high potency (0.05%).
• Betamethasone dipropionate: high potency (0.05%).
  
• Lotion: 0.05% (30 mL & 60 mL)
• Cream Ointment, or topical gel: 0.05% (15 g & 45 g)

Adverse-effects

• common (> 10%)

• temporary mild blurred vision
• increased appetite
• indigestion
• insomnia

• less common (1-10%)

• itching, burning, erythema, dryness, irritation, papular rashes, burning of eyes, burning of ears, cataracts, diabetes mellitus

• uncommon (< 1%)

• hypertrichosis, acne, perioral dermatitis, maceration of skin, skin atrophy, striae, miliaria, hypertension, sudden blindness, convulsions, vertigo, confusion, headache, thin fragile skin, sterile abscess, hyperpigmentation, hypopigmentation, Cushingoid state, peptic ulcer, itching, muscle weakness, osteoporosis, glaucoma, sodium retention, impaired wound healing

• miminal long-term (30 year) metabolic effects with antenatal exposure [3]
  

• drug adverse effects of glucocorticoids
• drug adverse effects of immunosuppressive agents

Drug-interactions

• aminoglutethimide
• anticholinesterases
• barbiturates
• carbamazepine
• phenytoin
• rifampin
• live virus vaccines
  
• drug interaction(s) of glucocorticoids with warfarin

More General Terms

• glucocorticoid
• antipruritic agent

Internet Database

PubChem: 9782

References

1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
3. Journal Watch 25(14):110, 2005 Dalziel SR, Walker NK, Parag V, Mantell C, Rea HH, Rodgers A, Harding JE. Cardiovascular risk factors after antenatal exposure to betamethasone: 30-year follow-up of a randomised controlled trial. Lancet. 2005 May 28;365(9474):1856-62. PMID: [PubMed - in process&dopt=Abstract]
   - Dalziel SR, Liang A, Parag V, Rodgers A, Harding JE. Blood pressure at 6 years of age after prenatal exposure to betamethasone: follow-up results of a randomized, controlled trial. Pediatrics. 2004 Sep;114(3):e373-7. PMID: [1]

betamethasone (Celestone, Diprosone, Valisone, Diprolene, Soluspan)