Beta Klotho

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 More General Terms 5 Internet Database 6 References

Function

• role in transcriptional repression of cholesterol 7-alpha-hydroxylase ( CYP7A1 (rate-limiting enzyme in bile acid synthesis)
• probably inactive as a glycosidase

Structure

• contains 2 glycosyl hydrolase 1 regions
• 1st region lacks essential Glu active site at position 241
• 2nd region lacks essential Glu active site at position 889
• domains are predicted to be inactive.
• belongs to the glycosyl hydrolase 1 family, Klotho subfamily

Compartment

• membrane

More General Terms

• membrane protein
• glycoprotein

Internet Database

Prosite: [1]
Prosite: [2]
UniProt: [3]

References

UniProt [4]

beta-klotho (betaKlotho, klotho beta-like protein, KLB)